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KMID : 0379519990150030345
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한국독성학회지
1999 Volume.15 No. 3 p.345 ~ p.352
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Changes in Xylene Metabolism in Rats Induced Various Degree of Liver Damage with CCl₄
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Lee Hye-Ja
Yoon Chong-Guk
Park Won-Hark
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Abstract
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To evaluate an effect of various degree of liver damage on xylene metabolism, a study was conducted. Various degree of liver damage was induced in rats with pretreatment of 50% CCl₄in olive oil (0.1 ml/100 g body weight) intraperitoneally every other day 4, 8, 12 and 16 times. Xylene was administered to the animals after 24 hours since the last pretreatment of CCl₄. Rats were sacrificed after 24 hours since the last injection of these xenobiotics. The increasing rate of liver weight/body weight (%), serum ALT activities and hepatic peroxide contents showed a gradual increase from the first group, 4 times injection of CCl₄, throughout the whole course of the experiments. In all groups, the ultrastructural changes revealed in the liver cells as time elapsed. In the present experimental animal model, by the xylene treatment the urinary hippuric acid concentration and hepatic aniline hydroxylase activities were lower in all liver damaged animals than control, but different values were not found among these liver damaged animal groups. On the other hand, hepatic alcohol dehydrogenase activities showed the similar between the xylene treated rats pretreated with CCl₄four times and only xylene treated rats, but these enzyme activities showed a gradual decrease from the first group, xylene treated animals pretreated CCl₄four times, throughout the experiments. Furthermore, hepatic aldehyde dehydrogenase activities were more significantly decreased in all CCl₄pretreated groups and by the pretreatment of CCl₄decreased values of these enzyme in xylene treated animals were rather gradually increased throughout the whole course of experiments. These results suggested that the rats induced liver damage with CCl₄may reduce the xylene metabolism. But the degree of liver damage with CCl₄under acute conditions may not influence upon the xylene metabolism.
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KEYWORD
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Liver damage, Xylene metabolism
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